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Andrew Patterson

Profile Photo
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Email
adp117@psu.edu
Telephone
(814) 867-4565

322 Life Sciences Bldg
Shortlidge Road
University Park, PA 16802

Elsevier Pure Profile
IEE Research Themes
Health and the Environment
Affiliate Researcher
Titles and Affiliations
Professor, Veterinary and Biomedical Sciences

Research Summary

Research is focused on defining the role of PPARa in mitochondrial dysfunction associated with drug-induced hepatotoxicity. Perhaps the most critical role of PPARa is to modulate hepatic fatty acid catabolism. Research utilizes mouse models, traditional biochemistry and molecular biology techniques, as well as cutting-edge and highly sophisticated metabolomic approaches to understand the molecular mechanisms associated with PPARa activity.

In the News

Research Keywords

 These keywords and phrases come from the publications and other research output of this person. See other researchers related to these topics by clicking on any keyword.

Metabolomics
Gastrointestinal Microbiome
Microbiota
Pharmacological Metabolism
Aryl Hydrocarbon Receptors
Metabolic
Bile Acids And Salts
Mass Spectrometry
Liver
Diet
Non-alcoholic Fatty Liver Disease
Homeostasis
Metabolite
Muricholic Acid
Bile Acid
Peroxisome Proliferator-Activated Receptors
Hydrocarbon
Metabolome
Liquid Chromatography
Lipid Metabolism

Projects

Microscopic visualization of neurons
Linking Environmental Toxicants to Neurodegenerative Processes
Shapes symbolizing gut microbiota
Modeling the Host-Gut Microbiota Metabolic Interactions to Elucidate the Role of Perfluorooctane Sulfanate on Obesity Outcomes
Understanding the Impact of Persistent Environmental Chemicals on the Gut Microbiome

Recent Publications

Individualized microbiotas dictate the impact of dietary fiber on colitis sensitivity

Bonazzi, E., Bretin, A., Vigué, L., Hao, F., Patterson, A. D., Gewirtz, A. T. & Chassaing, B., Dec 2024, In: Microbiome. 12, 1, 5.

Research output: Contribution to journal › Article › peer-review

Immune cell-intrinsic Ah receptor facilitates the expression of antimicrobial REG3G in the small intestine

Chakraborty, D., Coslo, D. M., Murray, I. A., Vijay, A., Patterson, A. D. & Perdew, G. H., Feb 29 2024, In: FASEB Journal. 38, 4, e23471.

Research output: Contribution to journal › Article › peer-review

Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption

Daniel, N., Wu, G. D., Walters, W., Compher, C., Ni, J., Delaroque, C., Albenberg, L., Ley, R. E., Patterson, A. D., Lewis, J. D., Gewirtz, A. T. & Chassaing, B., Jan 2024, In: CMGH. 17, 2, p. 315-318 4 p.

Research output: Contribution to journal › Short survey › peer-review

Reverse metabolomics for the discovery of chemical structures from humans

Gentry, E. C., Collins, S. L., Panitchpakdi, M., Belda-Ferre, P., Stewart, A. K., Carrillo Terrazas, M., Lu, H. H., Zuffa, S., Yan, T., Avila-Pacheco, J., Plichta, D. R., Aron, A. T., Wang, M., Jarmusch, A. K., Hao, F., Syrkin-Nikolau, M., Vlamakis, H., Ananthakrishnan, A. N., Boland, B. S., Hemperly, A., & 10 othersVande Casteele, N., Gonzalez, F. J., Clish, C. B., Xavier, R. J., Chu, H., Baker, E. S., Patterson, A. D., Knight, R., Siegel, D. & Dorrestein, P. C., Feb 8 2024, In: Nature. 626, 7998, p. 419-426 8 p.

Research output: Contribution to journal › Article › peer-review

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D., Amin, S., & 10 othersColeman, J. P., Shah, Y. M., Bisanz, J. E., Gonzalez, F. J., Vanden Heuvel, J. P., Wu, G. D., Zemel, B. S., Dorrestein, P. C., Weinert, E. E. & Patterson, A. D., Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.

Research output: Contribution to journal › Article › peer-review

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Zuffa, S., Schmid, R., Bauermeister, A., Paulo, P. W., Caraballo-Rodriguez, A. M., El Abiead, Y., Aron, A. T., Gentry, E. C., Zemlin, J., Meehan, M. J., Avalon, N. E., Cichewicz, R. H., Buzun, E., Terrazas, M. C., Hsu, C. Y., Oles, R., Ayala, A. V., Zhao, J., Chu, H., Kuijpers, M. C. M., & 89 othersJackrel, S. L., Tugizimana, F., Nephali, L. P., Dubery, I. A., Madala, N. E., Moreira, E. A., Costa-Lotufo, L. V., Lopes, N. P., Rezende-Teixeira, P., Jimenez, P. C., Rimal, B., Patterson, A. D., Traxler, M. F., Pessotti, R. D. C., Alvarado-Villalobos, D., Tamayo-Castillo, G., Chaverri, P., Escudero-Leyva, E., Quiros-Guerrero, L. M., Bory, A. J., Joubert, J., Rutz, A., Wolfender, J. L., Allard, P. M., Sichert, A., Pontrelli, S., Pullman, B. S., Bandeira, N., Gerwick, W. H., Gindro, K., Massana-Codina, J., Wagner, B. C., Forchhammer, K., Petras, D., Aiosa, N., Garg, N., Liebeke, M., Bourceau, P., Kang, K. B., Gadhavi, H., de Carvalho, L. P. S., Silva dos Santos, M., Pérez-Lorente, A. I., Molina-Santiago, C., Romero, D., Franke, R., Brönstrup, M., Vera Ponce de León, A., Pope, P. B., La Rosa, S. L., La Barbera, G., Roager, H. M., Laursen, M. F., Hammerle, F., Siewert, B., Peintner, U., Licona-Cassani, C., Rodriguez-Orduña, L., Rampler, E., Hildebrand, F., Koellensperger, G., Schoeny, H., Hohenwallner, K., Panzenboeck, L., Gregor, R., O’Neill, E. C., Roxborough, E. T., Odoi, J., Bale, N. J., Ding, S., Sinninghe Damsté, J. S., Guan, X. L., Cui, J. J., Ju, K. S., Silva, D. B., Silva, F. M. R., da Silva, G. F., Koolen, H. H. F., Grundmann, C., Clement, J. A., Mohimani, H., Broders, K., McPhail, K. L., Ober-Singleton, S. E., Rath, C. M., McDonald, D., Knight, R., Wang, M. & Dorrestein, P. C., Feb 2024, In: Nature Microbiology. 9, 2, p. 336-345 10 p.

Research output: Contribution to journal › Article › peer-review

Changes in fecal lipidome after treatment with ivacaftor without changes in microbiome or bile acids

Bass, R., Tanes, C., Bittinger, K., Li, Y., Lee, H., Friedman, E. S., Koo, I., Patterson, A. D., Liu, Q., Wu, G. D. & Stallings, V. A., 2023, (Accepted/In press) In: Journal of Cystic Fibrosis.

Research output: Contribution to journal › Article › peer-review

Psyllium Fiber Protects Against Colitis Via Activation of Bile Acid Sensor Farnesoid X Receptor

Bretin, A., Zou, J., San Yeoh, B., Ngo, V. L., Winer, S., Winer, D. A., Reddivari, L., Pellizzon, M., Walters, W. A., Patterson, A. D., Ley, R., Chassaing, B., Vijay-Kumar, M. & Gewirtz, A. T., Jan 2023, In: CMGH. 15, 6, p. 1421-1442 22 p.

Research output: Contribution to journal › Article › peer-review

Molecular networking identifies an AHR-modulating benzothiazole from white button mushrooms (Agaricus bisporus)

Chen, X., Patterson, A. D., Perdew, G. H., Murray, I. A. & Kellogg, J. J., Jul 2023, In: Journal of Functional Foods. 106, 105602.

Research output: Contribution to journal › Article › peer-review

Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Collins, S. L., Stine, J. G., Bisanz, J. E., Okafor, C. D. & Patterson, A. D., Apr 2023, In: Nature Reviews Microbiology. 21, 4, p. 236-247 12 p.

Research output: Contribution to journal › Review article › peer-review

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010

Research output: Contribution to journal › Article › peer-review

Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

Dong, F., Annalora, A. J., Murray, I. A., Tian, Y., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journal › Article › peer-review

Comparative urine metabolomics of mice treated with non-toxic and toxic oral doses of (−)-epigallocatechin-3-gallate

Hwang, S., Koo, I., Patterson, A. D. & Lambert, J. D., Oct 2 2023, In: Food and Function. 14, 20, p. 9434-9445 12 p.

Research output: Contribution to journal › Article › peer-review

Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation

Misra, S., Lee, T. J., Sebastian, A., McGuigan, J., Liao, C., Koo, I., Patterson, A. D., Rossi, R. M., Hall, M. A., Albert, I. & Prabhu, K. S., Feb 2023, In: Redox Biology. 59, 102571.

Research output: Contribution to journal › Article › peer-review

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation

Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journal › Article › peer-review