The Emerging Frontiers in Research and Innovation (EFRI) program of the NSF Directorate for Engineering (ENG) serves a critical role in helping ENG focus on important emerging areas in a timely manner. This solicitation is a funding opportunity for interdisciplinary teams of researchers to embark on rapidly advancing frontiers of fundamental engineering research. For this solicitation, we will consider proposals that aim to investigate emerging frontiers in the following two research areas: <ul> <li>Chromatin and Epigenetic Engineering (CEE)</li> <li>Continuum, Compliant, and Configurable Soft Robotics Engineering(C3 SoRo) </li> </ul> This solicitationwill becoordinated with the Directorate for Biological Sciences (BIO) andthe Directorate for Computer and Information Science and Engineering (CISE). EFRI seeks proposals with transformative ideas that represent an opportunity for a significant shift in fundamental engineering knowledge with a strong potential for long term impact on national needs or a grand challenge. The proposals must also meet the detailed requirements delineated in this solicitation. INFORMATIONAL WEBCAST: The Emerging Frontiers and Multidisciplinary Activities (EFMA) Office will host an informationalwebinar onSeptember 7th, 2017 at 1:00 PM ESTto discuss the EFRI program and answer questions aboutthe FY 2018 solicitation. Details on how to join this webinar will be posted on the<a href="https://www.nsf.gov/div/index.jsp?div=EFMA">EFMA Website</a>.