From New York City: The suggested route is via the George Washington Bridge to I-80. In Pennsylvania, take I-80 to exit 161 (Bellefonte) and follow PA Route 220 south to State College. Take exit 74 for Innovation Park / Penn State University.

From the Philadelphia Area: From the Philadelphia Schuylkill Expressway, follow the Pennsylvania Turnpike to exit 247 (Harrisburg East). Proceed on I-283 to I-83 and then to the I-81 interchange. Follow I-81 west to Route 322, 22 west exit. Take Route 322 west through Lewistown to State College (exit 74).

From Pittsburgh: Follow US Route 22 to Duncansville, I-99 / Route 220 north to Route 322 east to Mt. Nittany Expressway / State College (exit 73). From the West: Take I-80 to exit 123 (Woodland) just east of Clearfield, US Route 322 east to State College, or exit I-80 at Exit 161 (Bellefonte) and follow PA Route 220 south to State College.

From Washington, D.C.: Several routes are available. Take I-270 to Frederick, I-70 to Breezewood, the PA turnpike (exit 12) west to Bedford (exit 11), I-99 north to Rt. 220, and Route 322 East to State College; or take I-95 (or the Baltimore-Washington Parkway) to Baltimore, west loop I-695 to I-83 north, I-83 north to the I-81 interchange, I-81 west to Route 322, and Route 322 west to State College.

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