Shantu Amin

Affiliate Researcher
Titles and Affiliations
Professor, Department of Pharmacology

Research Summary

Mechanisms of chemical carcinogenesis as a tool for developing chemopreventive strategies to reduce the morbidity and mortality from cancer. In particular focusing on structure-activity studies with mutagenic and carcinogenic polycyclic aromatic hydrocarbons (PAHs).

In the News

Research Keywords

Recent Publications

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Rimal, B., Collins, S. L., Tanes, C. E., Rocha, E. R., Granda, M. A., Solanki, S., Hoque, N. J., Gentry, E. C., Koo, I., Reilly, E. R., Hao, F., Paudel, D., Singh, V., Yan, T., Kim, M. S., Bittinger, K., Zackular, J. P., Krausz, K. W., Desai, D., Amin, S., & 10 othersColeman, J. P., Shah, Y. M., Bisanz, J. E., Gonzalez, F. J., Vanden Heuvel, J. P., Wu, G. D., Zemel, B. S., Dorrestein, P. C., Weinert, E. E. & Patterson, A. D., Feb 22 2024, In: Nature. 626, 8000, p. 859-863 5 p.

Research output: Contribution to journalArticlepeer-review

Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[def,p]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity

Chen, K-M., Sun, Y-W., Hu, J., Balogh, K., Gowda, K., Aliaga, C., Sun, D., Christensen, N., Amin, S. & El-Bayoumy, K., 2023, (Accepted/In press) In: ACS Omega.

Research output: Contribution to journalArticlepeer-review

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

Dong, F., Murray, I. A., Annalora, A., Coslo, D. M., Desai, D., Gowda, K., Yang, J., Wang, D., Koo, I., Hao, F., Amin, S. G., Patterson, A. D., Marcus, C. & Perdew, G. H., Jul 1 2023, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37, 7, p. e23010

Research output: Contribution to journalArticlepeer-review

Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases

Kale, V. P., Hengst, J. A., Sharma, A. K., Golla, U., Dovat, S., Amin, S. G., Yun, J. K. & Desai, D. H., Aug 2023, In: Pharmaceuticals. 16, 8, 1060.

Research output: Contribution to journalArticlepeer-review

Selenocoxib-3, a novel anti-inflammatory therapeutic effectively resolves colitis

Kaur, R., Desai, D., Amin, S., Raza, K., Bhalla, A., Yadav, P. & Kaushal, N., Mar 2023, In: Molecular and Cellular Biochemistry. 478, 3, p. 621-636 16 p.

Research output: Contribution to journalArticlepeer-review

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation

Morgan, E. W., Dong, F., Annalora, A. J., Murray, I. A., Wolfe, T., Erickson, R., Gowda, K., Amin, S. G., Petersen, K. S., Kris-Etherton, P. M., Marcus, C. B., Walk, S. T., Patterson, A. D. & Perdew, G. H., Jan 1 2023, In: International Journal of Tryptophan Research. 16

Research output: Contribution to journalArticlepeer-review

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites

Patel, D., Murray, I. A., Dong, F., Annalora, A. J., Gowda, K., Coslo, D. M., Krzeminski, J., Koo, I., Hao, F., Amin, S. G., Marcus, C. B., Patterson, A. D. & Perdew, G. H., Sep 2023, In: Metabolites. 13, 9, 985.

Research output: Contribution to journalArticlepeer-review

Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders

Rikken, G., Smith, K. J., van den Brink, N. J. M., Smits, J. P. H., Gowda, K., Alnemri, A., Kuzu, G. E., Murray, I. A., Lin, J. M., Smits, J. G. A., van Vlijmen-Willems, I. M., Amin, S. G., Perdew, G. H. & van den Bogaard, E. H., Feb 2023, In: Biochemical Pharmacology. 208, 115400.

Research output: Contribution to journalArticlepeer-review

Aryl Hydrocarbon Receptor Activation Coordinates Mouse Small Intestinal Epithelial Cell Programming

Zhou, X., Chakraborty, D., Murray, I. A., Coslo, D., Kehs, Z., Vijay, A., Ton, C., Desai, D., Amin, S. G., Patterson, A. D. & Perdew, G. H., Feb 1 2023, In: Laboratory Investigation. 103, 2, p. 100012 1 p.

Research output: Contribution to journalArticlepeer-review

Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice

Zhu, X., Liu, Q., Patterson, A. D., Sharma, A. K., Amin, S. G., Cohen, S. M., Gonzalez, F. J. & Peters, J. M., Aug 2023, In: Metabolites. 13, 8, 936.

Research output: Contribution to journalArticlepeer-review

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells

Alden, N. A., Arrizabalaga, J. H., Liu, Y., Amin, S., Gowda, K., Yao, S., Archetti, M., Glick, A. B. & Hayes, D. J., Aug 16 2022, In: Langmuir. 38, 32, p. 9833-9843 11 p.

Research output: Contribution to journalArticlepeer-review

Black Raspberry Extract Enhances Glutathione Conjugation of the Fjord-Region Diol Epoxide Derived from the Tobacco Carcinogen Dibenzo[ def, p]chrysene in Human Oral Cells

Chen, K. M., Sun, Y. W., Sun, D., Gowda, K., Amin, S. & El-Bayoumy, K., Nov 21 2022, In: Chemical research in toxicology. 35, 11, p. 2152-2159 8 p.

Research output: Contribution to journalArticlepeer-review

Detection of DNA adducts derived from the tobacco carcinogens, benzo[a]pyrene and dibenzo[def,p]chrysene in human oral buccal cells

Chen, K. M., Sun, Y. W., Krebs, N. M., Sun, D., Krzeminski, J., Reinhart, L., Gowda, K., Amin, S., Mallery, S., Richie, J. P. & El-Bayoumy, K., Aug 1 2022, In: Carcinogenesis. 43, 8, p. 746-753 8 p.

Research output: Contribution to journalArticlepeer-review

Drug-Tolerant Persister Cells in Cancer Therapy Resistance

Dhanyamraju, P. K., Schell, T. D., Amin, S. & Robertson, G. P., Jul 15 2022, In: Cancer Research. 82, 14, p. 2503-2514 12 p.

Research output: Contribution to journalReview articlepeer-review

Targeting Protein Translation in Melanoma by Inhibiting EEF-2 Kinase Regulates Cholesterol Metabolism though SREBP2 to Inhibit Tumour Development

Dinavahi, S. S., Chen, Y. C., Gowda, R., Dhanyamraju, P. K., Punnath, K., Desai, D., Berg, A., Kimball, S. R., Amin, S., Yang, J. M. & Robertson, G. P., Apr 1 2022, In: International journal of molecular sciences. 23, 7, 3481.

Research output: Contribution to journalArticlepeer-review