Professor of Immunology and Molecular Toxicology
Co-Leader, Mechanisms of Carcinogenesis Program, Penn State Cancer Institute
College of Agricultural Sciences
Phone number(s): 
(814) 863-8976
Office Address: 
101 Henning Building
PSIEE Research Theme: 
Health and the Environment
Research Summary: 

Research interests include regulation of gene expression by oxidative, glycative and hypertonic stressors; molecular mechanisms underlying the antioxidant role of selenium; lipid biochemistry-prostaglandins, leukotrienes and oxidized fatty acids as nuclear receptor ligands. Current research areas include regulation of pro-inflammatory gene expression by oxidative stress-dependent mechanisms and the role of selenium in macrophages, isolation and characterization of endogenous ligands for the peroxisome proliferator-activated receptors (PPARs), and targeting of leukemia stem cells.