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Keith Cheng

Profile Photo
Image
Email
kcc2@psu.edu
Telephone
(717) 531-5635

H059 Pathology
Hershey, PA 17033

Elsevier Pure Profile
IEE Research Themes
Health and the Environment
Affiliate Researcher
Titles and Affiliations
Distinguished Professor, Department of Pathology and Laboratory Medicine
Distinguished Professor, Department of Biochemistry and Molecular Biology
Distinguished Professor, Department of Pharmacology

Research Summary

Research interests include the fundamental genetic and molecular mechanisms that cause cancer, basic mechanisms underlying the relationship between human skin pigmentation and cancer, and contributing to web-based infrastructures for science, education, and public service.

In the News

Research Keywords

 These keywords and phrases come from the publications and other research output of this person. See other researchers related to these topics by clicking on any keyword.

Zebrafish
Histology
Skin Pigmentation
Pigmentation
Mutation
Tissue
Phenotype
Synchrotrons
Larva
Genes
Genomic Instability
Microsatellite Repeats
Melanosomes
X-Ray Microtomography
Glutaric Acidemia I
Melanins
Brain
DNA
Genetic Recombination
Vertebrates

Recent Publications

Native American genetic ancestry and pigmentation allele contributions to skin color in a caribbean population

Ang, K. C., Canfield, V. A., Foster, T. C., Harbaugh, T. D., Early, K. A., Harter, R. L., Reid, K. P., Leong, S. L., Kawasawa, Y. I., Liu, D. J., Hawley, J. W. & Cheng, K. C., 2023, In: eLife. 12, e77514.

Research output: Contribution to journal › Article › peer-review

Prehistoric human migration between Sundaland and South Asia was driven by sea-level rise

Kim, H. L., Li, T., Kalsi, N., Nguyen, H. T. T., Shaw, T. A., Ang, K. C., Cheng, K. C., Ratan, A., Peltier, W. R., Samanta, D., Pratapneni, M., Schuster, S. C. & Horton, B. P., Dec 2023, In: Communications Biology. 6, 1, 150.

Research output: Contribution to journal › Article › peer-review

Sinogram domain angular upsampling of sparse-view micro-CT with dense residual hierarchical transformer and attention-weighted loss

Subbakrishna Adishesha, A., Vanselow, D. J., La Riviere, P., Cheng, K. C. & Huang, S. X., Dec 2023, In: Computer Methods and Programs in Biomedicine. 242, 107802.

Research output: Contribution to journal › Article › peer-review

Promoting validation and cross-phylogenetic integration in model organism research

Cheng, K. C., Burdine, R. D., Dickinson, M. E., Ekker, S. C., Lin, A. Y., Lloyd, K. C. K., Lutz, C. M., MacRae, C. A., Morrison, J. H., O'Connor, D. H., Postlethwait, J. H., Rogers, C. D., Sanchez, S., Simpson, J. H., Talbot, W. S., Wallace, D. C., Weimer, J. M. & Bellen, H. J., Sep 2022, In: DMM Disease Models and Mechanisms. 15, 9, dmm049600.

Research output: Contribution to journal › Article › peer-review

Whole-Brain Wiring Diagram of Oxytocin System in Adult Mice

Son, S., Manjila, S. B., Newmaster, K. T., Wu, Y. T., Vanselow, D. J., Ciarletta, M., Anthony, T. E., Cheng, K. C. & Kim, Y., Jun 22 2022, In: Journal of Neuroscience. 42, 25, p. 5021-5033 13 p.

Research output: Contribution to journal › Article › peer-review

Quantitative relationship between cerebrovascular network and neuronal cell types in mice

Wu, Y. T., Bennett, H. C., Chon, U., Vanselow, D. J., Zhang, Q., Muñoz-Castañeda, R., Cheng, K. C., Osten, P., Drew, P. J. & Kim, Y., Jun 21 2022, In: Cell Reports. 39, 12, 110978.

Research output: Contribution to journal › Article › peer-review

A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale

Yakovlev, M. A., Vanselow, D. J., Ngu, M. S., Zaino, C. R., Katz, S. R., Ding, Y., Parkinson, D., Wang, S. Y., Ang, K. C., La Riviere, P. & Cheng, K. C., Mar 1 2022, In: Journal of Synchrotron Radiation. 29, p. 505-514 10 p.

Research output: Contribution to journal › Article › peer-review

Whole-organism 3d quantitative characterization of zebrafish melanin by silver deposition micro-ct

Katz, S. R., Yakovlev, M. A., Vanselow, D. J., Ding, Y., Lin, A. Y., Parkinson, D. Y., Wang, Y., Canfield, V. A., Ang, K. C. & Cheng, K. C., Sep 2021, In: eLife. 10, e68920.

Research output: Contribution to journal › Article › peer-review

Chemical Imaging of Retinal Pigment Epithelium in Frozen Sections of Zebrafish Larvae Using ToF-SIMS

Van Nuffel, S., Ang, K. C., Lin, A. Y. & Cheng, K. C., Jan 6 2021, In: Journal of the American Society for Mass Spectrometry. 32, 1, p. 255-261 7 p.

Research output: Contribution to journal › Article › peer-review

Selective synthetic augmentation with HistoGAN for improved histopathology image classification

Xue, Y., Ye, J., Zhou, Q., Long, L. R., Antani, S., Xue, Z., Cornwell, C., Zaino, R., Cheng, K. C. & Huang, X., Jan 2021, In: Medical Image Analysis. 67, 101816.

Research output: Contribution to journal › Article › peer-review

A map of cis-regulatory elements and 3D genome structures in zebrafish

Yang, H., Luan, Y., Liu, T., Lee, H. J., Fang, L., Wang, Y., Wang, X., Zhang, B., Jin, Q., Ang, K. C., Xing, X., Wang, J., Xu, J., Song, F., Sriranga, I., Khunsriraksakul, C., Salameh, T., Li, D., Choudhary, M. N. K., Topczewski, J., & 6 othersWang, K., Gerhard, G. S., Hardison, R. C., Wang, T., Cheng, K. C. & Yue, F., Dec 10 2020, In: Nature. 588, 7837, p. 337-343 7 p.

Research output: Contribution to journal › Article › peer-review

Enhanced and unified anatomical labeling for a common mouse brain atlas

Chon, U., Vanselow, D. J., Cheng, K. C. & Kim, Y., Dec 1 2019, In: Nature communications. 10, 1, 5067.

Research output: Contribution to journal › Article › peer-review

Computational 3d histological phenotyping of whole zebrafish by x-ray histotomography

Ding, Y., Vanselow, D. J., Yakovlev, M. A., Katz, S. R., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., Carlo, F. D., Rossum, D. B. V., Riviere, P. L. & Cheng, K. C., May 2019, In: eLife. 8, e44898.

Research output: Contribution to journal › Article › peer-review

Abstracts of Presentations at the Association of Clinical Scientists 139th Meeting Hershey, PA, May 15-18, 2019

Donaldson, K., Buchanich, J. M., Grigson, P. S., Deneke, E., Vrana, K. E., Sacks, D. B., Kuehn, G. J., Cardamone, D., Pesce, A., Smiley, S., Nickley, J., Krock, K., Thomas, R., Wilkerson, M. L., Farag, H. A., Challa, S. R., Tice, A. M., Wolk, D. M., Prichard, J., Grant, M. L., & 102 othersRegmi, S., Kerbacher, B., Quinton, L. E., Tice, A. M., Olson, J., Haynes, A., Yu, E., McCully, K. S., Assi, J., Wong, M., Zarrin-Khameh, N., Nifong, T. P., Hawker, C. D., Carlton, G. T., Rivera, J. M., Foulis, P. R., Zuraw, A., Morlote, D., Peker, D., Reddy, V., Harada, S., Crutchfield, C., Zander, D., Barbhuiya, M. A., Pederson, E. C., Straub, M. L., Scott, S. C., Neibauer, T. L., Salter, W. F., Creer, M. H., Zhu, Y., Bornhorst, J. A., Theobald, J. P., Algeciras-Schimnich, A., Cao, L., Knox, J., Hardy, R., Texas, H. J., McGuire, M. F., Hunter, R. L., Brown, R. E., Hicks, J., Cai, Z., Brown, R. E., Ali, Y., Cheng, K. C., Katz, S. R., Ding, Y., Vanselow, D. J., Yakovlev, M. A., Lin, A. Y., Clark, D. P., Vargas, P., Xin, X., Copper, J. E., Canfield, V. A., Ang, K. C., Wang, Y., Xiao, X., De Carlo, F., van Rossum, D. B., La Rivière, P. J., Newell, J., Hossler, C., Roche, M., Warrick, J., Phaeton, R., Kesterson, J., Myers, C., Barrios, R., Mintz, P., Robyak, K., Hamilton, C., McGhee, P., Pederson, C., Straub, M., Scott, S., Neibauer, T., Salter, W., Robyak, K., Singh, N., Morlote, D., Vnencak-Jones, C., Yemelyanova, A., Harada, S., Shah, M., Moghadamtousi, S. Z., Lan, C., Duose, D., Hu, P., Esquenazi, Y., Luthra, R., Ballester, L. Y., Koenig, A. N., Liu, C. G., Zhang, J., Kalia, A., Al-Habib, A., Van Arsdall, M., Dhingra, S., Patel, K. & Tatevian, N., May 1 2019, In: Annals of clinical and laboratory science. 49, 3, p. 403-416 14 p.

Research output: Contribution to journal › Article › peer-review

Identification of African-Specific Admixture between Modern and Archaic Humans

the GenomeAsia 100K Consortium, Dec 5 2019, In: American Journal of Human Genetics. 105, 6, p. 1254-1261 8 p.

Research output: Contribution to journal › Article › peer-review