Research Summary
Focuses on the development of rational design methods for engineering synthetic biological systems - metabolic pathways, genetic circuits and genomes. He develops kinetic and thermodynamic models of genetic regulation and tests those predictions in industrially and medically useful microorganisms to gain a quantitative understanding of genetic function. He also programs synthetic microorganisms to manufacture useful chemicals for bioenergy applications and to better understand the dynamical behavior of natural microorganisms.
In the News
Research Keywords
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Recent Publications
Genetic circuitry boosts cell longevity
Salis, H. M., Apr 28 2023, In: Science. 380, 6643, p. 343 1 p.Research output: Contribution to journal › Article › peer-review
Automated design of protein-binding riboswitches for sensing human biomarkers in a cell-free expression system
Vezeau, G. E., Gadila, L. R. & Salis, H. M., Dec 2023, In: Nature communications. 14, 1, 2416.Research output: Contribution to journal › Article › peer-review
Automated model-predictive design of synthetic promoters to control transcriptional profiles in bacteria
LaFleur, T. L., Hossain, A. & Salis, H. M., Dec 2022, In: Nature communications. 13, 1, 5159.Research output: Contribution to journal › Article › peer-review
Systematic Quantification of Sequence and Structural Determinants Controlling mRNA stability in Bacterial Operons
Cetnar, D. P. & Salis, H. M., Feb 19 2021, In: ACS Synthetic Biology. 10, 2, p. 318-332 15 p.Research output: Contribution to journal › Article › peer-review
Selenium-dependent metabolic reprogramming during inflammation and resolution
Korwar, A. M., Hossain, A., Lee, T. J., Shay, A. E., Basrur, V., Conlon, K., Smith, P. B., Carlson, B. A., Salis, H. M., Patterson, A. D. & Prabhu, K. S., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100410.Research output: Contribution to journal › Article › peer-review
Purification of Cas9—RNA complexes by ultrafiltration
Manzano, I., Taylor, N., Csordas, M., Vezeau, G. E., Salis, H. M. & Zydney, A. L., Mar 1 2021, In: Biotechnology progress. 37, 2, e3104.Research output: Contribution to journal › Article › peer-review
Tuning Cell-Free Composition Controls the Time Delay, Dynamics, and Productivity of TX-TL Expression
Vezeau, G. E. & Salis, H. M., Oct 15 2021, In: ACS Synthetic Biology. 10, 10, p. 2508-2519 12 p.Research output: Contribution to journal › Article › peer-review
Synthesis Success Calculator: Predicting the Rapid Synthesis of DNA Fragments with Machine Learning
Halper, S. M., Hossain, A. & Salis, H. M., Jul 17 2020, In: ACS Synthetic Biology. 9, 7, p. 1563-1571 9 p.Research output: Contribution to journal › Article › peer-review
Automated design of thousands of nonrepetitive parts for engineering stable genetic systems
Hossain, A., Lopez, E., Halper, S. M., Cetnar, D. P., Reis, A. C., Strickland, D., Klavins, E. & Salis, H. M., Dec 2020, In: Nature Biotechnology. 38, 12, p. 1466-1475 10 p.Research output: Contribution to journal › Article › peer-review
Convolutional neural net learns promoter sequence features driving transcription strength
Leiby, N., Hossain, A. & Salis, H. M., Mar 11 2020, In: EPiC Series in Computing. 70, p. 163-172 10 p.Research output: Contribution to journal › Conference article › peer-review
RNA size and 3-dimensional structure determine ultrafiltration behavior of small RNA molecules
Manzano, I., Vezeau, G., Salis, H. & Zydney, A. L., Apr 15 2020, In: Separation and Purification Technology. 237, 116372.Research output: Contribution to journal › Article › peer-review
An automated model test system for systematic development and improvement of gene expression models
Reis, A. C. & Salis, H. M., Nov 20 2020, In: ACS Synthetic Biology. 9, 11, p. 3145-3156 12 p.Research output: Contribution to journal › Article › peer-review
Simultaneous repression of multiple bacterial genes using nonrepetitive extra-long sgRNA arrays
Reis, A. C., Halper, S. M., Vezeau, G. E., Cetnar, D. P., Hossain, A., Clauer, P. R. & Salis, H. M., Nov 1 2019, In: Nature Biotechnology. 37, 11, p. 1294-1301 8 p.Research output: Contribution to journal › Article › peer-review
Controlling Heterogeneity and Increasing Titer from Riboswitch-Regulated Bacillus subtilis Spores for Time-Delayed Protein Expression Applications
Tamiev, D., Lantz, A., Vezeau, G., Salis, H. & Reuel, N. F., Oct 18 2019, In: ACS Synthetic Biology. 8, 10, p. 2336-2346 11 p.Research output: Contribution to journal › Article › peer-review
A Canonical Biophysical Model of the CsrA Global Regulator Suggests Flexible Regulator-Target Interactions
Leistra, A. N., Gelderman, G., Sowa, S. W., Moon-Walker, A., Salis, H. M. & Contreras, L. M., Dec 1 2018, In: Scientific reports. 8, 1, 9892.Research output: Contribution to journal › Article › peer-review