Professor of Veterinary Science
H. Thomas and Dorothy Willits Hallowell Chair
Fellow, Academy of Toxicological Sciences
College of Agricultural Sciences
Email: 
cjo10@psu.edu
Phone number(s): 
(814) 863-1625
Office Address: 
306D Life Sciences Building
PSIEE Research Theme: 
Health and the Environment
Research Summary: 

Research is focused on the molecularbiology of mammalian biotransformation. Variability in the expression of biotransformation activities appears to substantially impact individual responsiveness to both pharmaceutical and toxicant exposures. One line of research relates to the study of the regulatory mechanisms responsible for controlling the expression of the biotransformation enzymes. A parallel investigation in the laboratory involves the characterization of the human epoxide hydrolases, including their structure, regulation and genetic variability.