Costas Maranas

Affiliate Researcher
Titles and Affiliations
Donald B. Broughton Professor, Chemical Engineering

Research Summary

Research interests include modeling/optimization of directed evolution protocols for protein engineering, optimization in metabolic engineering and bioinformatics, molecular and product design, and supply chain planning and scheduling.

In the News

Research Keywords

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Projects

Recent Publications

Data-driven and physics informed modeling of Chinese Hamster Ovary cell bioreactors

Cui, T., Bertalan, T., Ndahiro, N., Khare, P., Betenbaugh, M., Maranas, C. & Kevrekidis, I. G., Apr 2024, In: Computers and Chemical Engineering. 183, 108594.

Research output: Contribution to journalArticlepeer-review

De novo design and Rosetta-based assessment of high-affinity antibody variable regions (Fv) against the SARS-CoV-2 spike receptor binding domain (RBD)

Boorla, V. S., Chowdhury, R., Ramasubramanian, R., Ameglio, B., Frick, R., Gray, J. J. & Maranas, C. D., Feb 2023, In: Proteins: Structure, Function and Bioinformatics. 91, 2, p. 196-208 13 p.

Research output: Contribution to journalArticlepeer-review

Deuterated water as a substrate-agnostic isotope tracer for investigating reversibility and thermodynamics of reactions in central carbon metabolism

Callaghan, M. M., Thusoo, E., Sharma, B. D., Getahun, F., Stevenson, D. M., Maranas, C., Olson, D. G., Lynd, L. R. & Amador-Noguez, D., Nov 2023, In: Metabolic engineering. 80, p. 254-266 13 p.

Research output: Contribution to journalArticlepeer-review

A single amino acid change led to structural and functional differentiation of PvHd1 to control flowering in switchgrass

Choi, S., Prabhakar, P. K., Chowdhury, R., Pendergast, T. H., Urbanowicz, B. R., Maranas, C. & Devos, K. M., Sep 29 2023, In: Journal of experimental botany. 74, 18, p. 5532-5546 15 p.

Research output: Contribution to journalArticlepeer-review

Little Brown Bats (Myotis lucifugus) Support the Binding of SARS-CoV-2 Spike and Are Likely Susceptible to SARS-CoV-2 Infection

Chothe, S. K., Jakka, P., Boorla, V. S., Ramasamy, S., Gontu, A., Nissly, R. H., Brown, J., Turner, G., Sewall, B. J., Reeder, D. A. M., Field, K. A., Engiles, J. B., Amirthalingam, S., Ravichandran, A., LaBella, L., Nair, M. S., Maranas, C. D. & Kuchipudi, S. V., May 2023, In: Viruses. 15, 5, 1103.

Research output: Contribution to journalArticlepeer-review

A multi-organ maize metabolic model connects temperature stress with energy production and reducing power generation

Chowdhury, N. B., Simons-Senftle, M., Decouard, B., Quillere, I., Rigault, M., Sajeevan, K. A., Acharya, B., Chowdhury, R., Hirel, B., Dellagi, A., Maranas, C. & Saha, R., Dec 15 2023, In: iScience. 26, 12, 108400.

Research output: Contribution to journalArticlepeer-review

Evaluating proteome allocation of Saccharomyces cerevisiae phenotypes with resource balance analysis

Dinh, H. V. & Maranas, C. D., May 2023, In: Metabolic engineering. 77, p. 242-255 14 p.

Research output: Contribution to journalArticlepeer-review

Comparative study of two Saccharomyces cerevisiae strains with kinetic models at genome-scale

Hu, M., Dinh, H. V., Shen, Y., Suthers, P. F., Foster, C. J., Call, C. M., Ye, X., Pratas, J., Fatma, Z., Zhao, H., Rabinowitz, J. D. & Maranas, C. D., Mar 2023, In: Metabolic engineering. 76, p. 1-17 17 p.

Research output: Contribution to journalArticlepeer-review

A detailed genome-scale metabolic model of Clostridium thermocellum investigates sources of pyrophosphate for driving glycolysis

Schroeder, W. L., Kuil, T., van Maris, A. J. A., Olson, D. G., Lynd, L. R. & Maranas, C. D., May 2023, In: Metabolic engineering. 77, p. 306-322 17 p.

Research output: Contribution to journalArticlepeer-review

Rank-ordering of known enzymes as starting points for re-engineering novel substrate activity using a convolutional neural network

Upadhyay, V., Boorla, V. S. & Maranas, C. D., Jul 2023, In: Metabolic engineering. 78, p. 171-182 12 p.

Research output: Contribution to journalArticlepeer-review

Metabolic engineering of low-pH-tolerant non-model yeast, Issatchenkia orientalis, for production of citramalate

Wu, Z. Y., Sun, W., Shen, Y., Pratas, J., Suthers, P. F., Hsieh, P. H., Dwaraknath, S., Rabinowitz, J. D., Maranas, C. D., Shao, Z. & Yoshikuni, Y., Jun 2023, In: Metabolic Engineering Communications. 16, e00220.

Research output: Contribution to journalArticlepeer-review

EnZymClass: Substrate specificity prediction tool of plant acyl-ACP thioesterases based on ensemble learning

Banerjee, D., Jindra, M. A., Linot, A. J., Pfleger, B. F. & Maranas, C. D., Jan 2022, In: Current Research in Biotechnology. 4, p. 1-9 9 p.

Research output: Contribution to journalArticlepeer-review

ML helps predict enzyme turnover rates

Boorla, V. S., Upadhyay, V. & Maranas, C. D., Aug 2022, In: Nature Catalysis. 5, 8, p. 655-657 3 p.

Research output: Contribution to journalComment/debatepeer-review

Dissecting the metabolic reprogramming of maize root under nitrogen-deficient stress conditions

Chowdhury, N. B., Schroeder, W. L., Sarkar, D., Amiour, N., Quilleré, I., Hirel, B., Maranas, C. D. & Saha, R., Jan 5 2022, In: Journal of experimental botany. 73, 1, p. 275-291 17 p.

Research output: Contribution to journalArticlepeer-review

Quantifying the propagation of parametric uncertainty on flux balance analysis

Dinh, H. V., Sarkar, D. & Maranas, C. D., Jan 2022, In: Metabolic engineering. 69, p. 26-39 14 p.

Research output: Contribution to journalArticlepeer-review