Andrew Zydney

Affiliate Researcher
Titles and Affiliations
Distinguished Professor, Chemical Engineering

Research Summary

Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t

In the News

Research Keywords

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Projects

Recent Publications

Impact of proteins and protein fouling on virus retention during virus removal filtration

Afzal, M. A. & Zydney, A. L., Feb 2024, In: Biotechnology and bioengineering. 121, 2, p. 710-718 9 p.

Research output: Contribution to journalArticlepeer-review

Tangential flow filtration for continuous processing of crystallized proteins

Behboudi, A., Minervini, M., Kedzierski, A., Azzariti, L. & Zydney, A. L., May 25 2024, In: Separation and Purification Technology. 336, 126311.

Research output: Contribution to journalArticlepeer-review

Filtration of a multi-serotype glycoconjugate vaccine drug product through sterilizing grade 0.2/0.22 µm pore size filters

Du, Z., Qiu, S., Gill, K., Toprani, V. & Zydney, A. L., Feb 2024, In: Biotechnology Journal. 19, 2, 2300450.

Research output: Contribution to journalArticlepeer-review

Membrane technology for the purification of RNA and DNA therapeutics

Javidanbardan, A., Messerian, K. O. & Zydney, A. L., 2024, (Accepted/In press) In: Trends in Biotechnology.

Research output: Contribution to journalReview articlepeer-review

Optimizing particle morphology during antibody precipitation for enhanced tangential flow filtration performance

Minervini, M., Behboudi, A., Marzella, J. R. & Zydney, A. L., Jun 19 2024, In: Separation and Purification Technology. 338, 126574.

Research output: Contribution to journalArticlepeer-review

Co-current filtrate flow in TFF perfusion processes: Decoupling transmembrane pressure from crossflow to improve product sieving

Romann, P., Giller, P., Sibilia, A., Herwig, C., Zydney, A. L., Perilleux, A., Souquet, J., Bielser, J. M. & Villiger, T. K., Feb 2024, In: Biotechnology and bioengineering. 121, 2, p. 640-654 15 p.

Research output: Contribution to journalArticlepeer-review

The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes

Billups, M., Minervini, M., Holstein, M., Feroz, H., Ranjan, S., Hung, J. & Zydney, A. L., Dec 2023, In: Biotechnology Journal. 18, 12, 2300265.

Research output: Contribution to journalArticlepeer-review

Data-science-based reconstruction of 3-D membrane pore structure using a single 2-D micrograph

Chamani, H., Rabbani, A., Russell, K. P., Zydney, A. L., Gomez, E. D., Hattrick-Simpers, J. & Werber, J. R., Jul 15 2023, In: Journal of Membrane Science. 678, 121673.

Research output: Contribution to journalArticlepeer-review

Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications

Chaubal, A. S. & Zydney, A. L., Apr 2023, In: Membranes. 13, 4, 433.

Research output: Contribution to journalArticlepeer-review

Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins

Chu, L. K., Borujeni, E. E., Xu, X., Ghose, S. & Zydney, A. L., Jul 2023, In: Biotechnology and bioengineering. 120, 7, p. 1882-1890 9 p.

Research output: Contribution to journalArticlepeer-review

Sterile filtration of a multi-serotype glycoconjugate vaccine drug product

Du, Z., Gill, K., Toprani, V. & Zydney, A. L., May 2023, In: Biotechnology and bioengineering. 120, 5, p. 1316-1322 7 p.

Research output: Contribution to journalArticlepeer-review

Smart Manufacturing Implementation of a Continuous Downstream Precipitation and Filtration Process for Antibody Purification

Ghosh, S., Mergy, M., Minervini, M., Okpanum, J., Cramer, S. M., Bequette, B. W., Zydney, A. L. & Przybycien, T. M., Oct 6 2023, In: Smart and Sustainable Manufacturing Systems. 7, 1, p. 129-147 19 p.

Research output: Contribution to journalArticlepeer-review

Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles

Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., Oct 15 2023, In: Journal of Membrane Science. 684, 121896.

Research output: Contribution to journalArticlepeer-review

Continuous precipitation-filtration process for initial capture of a monoclonal antibody product using a four-stage countercurrent hollow fiber membrane washing step

Minervini, M., Mergy, M., Zhu, Y., Gutierrez Diaz, M. A., Pointer, C., Shinkazh, O., Oppenheim, S. F., Cramer, S. M., Przybycien, T. M. & Zydney, A. L., 2023, (Accepted/In press) In: Biotechnology and bioengineering.

Research output: Contribution to journalArticlepeer-review

High-performance countercurrent membrane purification for host cell protein removal from monoclonal antibody products

Mohammadzadehmarandi, A., Determan, A., Krumm, C., McIntosh, L. D. & Zydney, A. L., Dec 2023, In: Biotechnology and bioengineering. 120, 12, p. 3585-3591 7 p.

Research output: Contribution to journalArticlepeer-review